Glutathione synthesis in the mouse liver supports lipid abundance through NRF2 repression Nature Communications Hepatic Glutathione Synthesis: The Liver's Antioxidant Powerhouse Glutathione (GSH) is the most abundant intracellular antioxidantand the liver is its primary production site. Through a tightly regulated, ATP dependent pathway, hepatocytes Glycerol as a precursor for hepatic de novo glutathione synthesis in human liver ScienceDirect Dysregulation of glutathione synthesis in liver disease ScienceDirect GSH synthesis Glutathione Metabolism and Its Implications for Health ScienceDirect