Acetaminophen induces liver injury and depletes glutathione in mice brain: Prevention by Moringa oleifera extract ScienceDirect Is Tylenol Safe During Pregnancy? Understanding Risk Factors Seeking Health As a naturopathic doctor and a mom, Tylenol is a hard no in my house and I want to explain why. , , Acetaminophen (Tylenol) is processed through the liver, and in that process it can lower Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors. g glutamyl cycle. Depletion of glutathione by acetaminophen leads to Download Scientific Diagram Full article: The development and hepatotoxicity of acetaminophen: reviewing over a century of progress