G6PD Deficiency Glucose 6 phosphate dehydrogenase deficiency X linked recessive disorder Leads to low NADPH, impairing glutathione regeneration RBCs are vulnerable to oxidative damage Pathophysiology: In G6PD deficiency: No Pentose Phosphate Pathway made simple. This pathway has two major jobs: Generate NADPH Produce ribose 5 phosphate NADPH protects cells from oxidative stress and supports fatty acid, cholesterol, steroid, nitric oxide, and respiratory burst Safe fluoroquinolones prophylaxis in blood cancer patients with chemotherapyinduced neutropenia and Glucose6PhosphateDehydrogenase deficiency Sanna 2017 Journal of Clinical Pharmacy and Therapeutics Wiley Online Library Role of G6PD in managing oxidative stress Glutathione peroxidase Download Scientific Diagram The Pentose Phosphate Pathway & G6PD Deficiency , Blog: https: bit.ly pentosephosphatepathway; https: bit.ly g6pddeficiency, YouTube: https: youtu.be ITy2gkUD7eM , Key points about the Pentose Pathology of G6PD deficiency Pathology Made Simple