Ferroptosis and intrinsic drug induced liver injury by acetaminophen and other drugs: a critical evaluation and historical perspective EurekAlert! Illustration of the effects of acetaminophen on glutathione, Download Scientific Diagram Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors. 5 Oxoprolinuria as a Cause for Metabolic Acidosis Renal Fellow Network Acetylcysteine for Acetaminophen Poisoning New England Journal of Medicine Acetaminophen Overdose Reveals PAR4 as a Low Expressing but Potent Receptor on the Hepatic Endothelium in Mice Arteriosclerosis, Thrombosis, and Vascular Biology